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Price of gabapentin 300 mg + a 100 or 200 mg of bromfenac (100 mg/day) + fosinopril (2 mg/day). At first, the doses were divided according to the amount of gabapentin in patient's blood. However, this regimen required a long time and many blood tests to produce a maximum result in the clinical trials. Therefore, a more feasible approach was implemented. In this study, the minimum dose was used in which the plasma concentrations of gabapentin, bromfenac, and fosinopril reached an optimal target level using a continuous dose formulator. The maximal concentration determined by analyzer was set to the optimal target Gabapentin 120 pills 40 mg - 205.27$ level (100 ng/mL). During the pharmacokinetic analysis, it has been shown that the pharmacodynamic response to gabapentin, bromfenac, and fosinopril is similar. Therefore, the pharmacokinetics results will be presented in both the plasma and urine. However, pharmacodynamic analyses did not show any important differences between the plasma and urine. These results can be used for the planning of dose adjustment to clinical studies ( Table 2 ). Table 2. Baseline Characteristics (N=10) At (N=6) Placebo Gabapentin bromfenac (N=4) Fosinopril Dose of Gabapentin (mg/day) (mean) 600 450 250 400 200 300 N=6 in each group Placebo (N=6 group) Gabapentin in each Placebo (N=4) Mean (SD) 2.03 (1.78, 2.61) 2.17 (1.94, 2.54) 3.03 (2.16, 3.33) 2.59 (1.76, 3.06) 2.50 (1.75, 3.12) 3.37 (2.48, 4.15) Median (range) 4 (0–20) 2 (0–8) 5 (0–10) 3 (0–20) Median(range) 2 (0–8) 5 4 3 (0–10) (0–20) Mean, sd (range) 3.23 (2.60, 3.86) 4.03 (3.41, 4.86) 5.25 (5.04, 5.86) 3.65 (3.09, 4.25) 2.62 (2.23, 3.00) 2.89 (2.64, 3.38) Baseline Characteristics (N=10) At (N=6) Placebo Gabapentin bromfenac (N=4) Fosinopril Dose of Gabapentin (mg/day) (mean) 600 450 250 400.
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